Nikki Glaser came out swinging at the 2025 Golden Globes, opening her hosting debut with a monologue that poked fun at Diddy, “Dune: Part Two” and Timothée Chalamet in front of Hollywood’s A-list stars.

She began her monologue by calling the awards ceremony “Ozempic’s biggest night,” and told viewers on Paramount+, “You have six days left to cancel your free trial.”

“I’ve got to say, this feels like I finally made it. You know, I’m in a room full of producers at the Beverly Hilton hotel, and this time all of my clothes are on,” Glaser said to big laughs. “It was worth it.”

Running through some of the top nominees, Glaser said, “Tonight, we celebrate the best of film and hold space for television,” nodding to the viral “Wicked” press tour meme. “‘Wicked,’ ‘Queer,’ ‘Nightbitch’… these are not just words Ben Affleck yells after he orgasms, these are some of the incredible movies nominated tonight.”

Glaser continued, “‘The Bear,’ ‘The Penguin,’ ‘Baby Reindeer’… these are not just things found in RFK’s freezer, these are TV shows nominated tonight.”

The host called attention to “the hardest-working actors in show business” — the servers, who are bringing the celebrities in the room their “cocktails to drink” and “food to look at.”

Glaser took aim at Denis Villeneuve’s sci-fi sequel by praising Zendaya: “You were incredible in ‘Dune,’ oh my God. I woke up for all of your scenes!” As for Zendaya’s other 2024 film, “Challengers,” Glaser noted, “That movie was more sexually charged than Diddy’s credit card!”

Speaking of disgraced music mogul Diddy, accused of rape and sex trafficking, Glaser said, “I’m sorry, I’m upset too. The after-party isn’t going to be as good this year, but we have to move on. ‘Stanley Tucci freak-off’ doesn’t have the same ring to it.”

As the cameras cut to the “Conclave” star wincing in jest, Glaser added, “No baby oil this year, just lots of olive oil.”

Before praising his performance as Bob Dylan in “A Complete Unknown,” Glaser took aim at Chalamet’s facial hair, saying, “You have the most gorgeous eyelashes on your upper lip.”

Then, moving on to one of the biggest films of the night, Glaser said, “We can’t talk about movies tonight without talking about ‘Wicked.’ I did not know much about ‘Wicked’ going into this year, because I had friends in high school.”

“Everyone loved ‘Wicked,’” Glaser added. “I loved ‘Wicked,’ my boyfriend loved ‘Wicked,’ my boyfriend’s boyfriend really loved ‘Wicked.’”

Glaser went on, “At ‘Wicked,’ some people complained that the movie was ruined by people singing. And at ‘Joker 2,’ people complained that the movie was ruined by the images on the screen and the sounds that accompanied them.”

Digging in further on the ill-received Joaquin Phoenix and Lady Gaga musical, which did not receive a single Golden Globe nomination, Glaser said, “I’m sorry, ‘Joker 2.’ Where is their table? Oh, that’s right, they’re not here.”

Looking around the room, Glaser welcomed more celebrities to the show. “Thank you for working so hard,” she said to “Babygirl” star Nicole Kidman, seated next to her country music star husband. “And thank you to Keith Urban for playing guitar around the house so much that she wants to leave and make 18 movies a year!”

Glaser also greeted “two-time Holocaust survivor” Adrien Brody, in reference to his roles in 2024’s “The Brutalist” and 2002’s “The Pianist,” and Glen Powell, who this year was seen in “Twisters,” “Hit Man” and Glaser’s “head when I’m having sex with my boyfriend.”

She then welcomed Selena Gomez, who is double-nominated at the Globes for “Emilia Pérez” and “Only Murders in the Building,” and her new fiancé, music producer Benny Blanco, who Glaser joked “is here because of the genie who granted him that wish.”

Before introducing the first presenters, “Moana 2” stars Auliʻi Cravalho and Dwayne Johnson, Glaser seemingly took a playful shot at The Rock’s Teremana Tequila brand.

“Before we start handing out awards, I do want to remind you, if you do lose tonight, please just keep in mind that the point of making art is not to win an award,” Glaser said. “The point of making art is to start a tequila brand so popular that you never have to make art again.”

Glaser is best known for her roast material — she was the undisputed victor of Netflix’s “The Roast of Tom Brady” in 2024. As Globes host she succeeds Jo Koy, who led the ceremony in 2024 with a poorly received monologue that touched on Ozempic and Barry Keoghan’s genitals.

Ahead of her hosting stint, Glaser teased to Variety that she’d be targeting celebrities in the audience who “don’t have a sense of humor about themselves.” “If I were to make that person laugh, it shows the people in the room, ‘OK, it’s safe to laugh,’” Glaser said. “When you laugh at a joke about yourself, it makes you look so friendly, so cool, so personable. I’m trying to help you out. This way you don’t have to play Hip-Hop Hopscotch with Jimmy Fallon to look relatable.”

In addition to hosting the Globes, Glaser was nominated for best performance in stand-up comedy on television, for her HBO special “Someday You’ll Die.”

Variety parent company PMC owns Golden Globes producer Dick Clark Prods. in a joint venture with Eldridge.