With multiple wildfires raging in the Los Angeles area, some people fled their homes on Tuesday only to evacuate again soon after, as fast-growing fires in different parts of the county quickly turned safe havens into danger zones.

On Wednesday, tens of thousands of people were displaced by several major fires fueled by strong winds. Some residents, including Rob Sherman and his wife, Cecilia Peck, have been displaced more than once.

The Palisades fire forced them from their home in the Highlands area of Pacific Palisades on Tuesday. They drove through thick smoke and watched as flames blazed along Pacific Coast Highway on their way to stay with a friend in Eagle Rock, a neighborhood west of Pasadena. But by Wednesday morning, that home was also under an evacuation warning because of the Eaton fire.

“If it weren’t so serious, I would have thought it was kind of funny,” Mr. Sherman said. “But it is so serious. It’s all happening against a backdrop of life and death. I just felt, Another day to soldier on.”

The couple headed out again later in the morning, this time bound for a friend’s place in Temecula, Calif., about 90 miles southeast.

Some people were trying to figure out where they could go that would be free of smoke — and accessible, given the active blazes.

Rochelle Duffy, 79, and her husband were staying at a friend’s home in Altadena, Calif., for a week when the Eaton fire erupted. On Tuesday evening, they went to another friend’s home in Arcadia before leaving for a third home in nearby Monrovia around 2:30 a.m. The drive was short but eerie, Ms. Duffy said, because the power and all the lights were out.

On Wednesday, the couple were trying to decide whether to go north to Santa Barbara.

“We need to find out: Is the freeway available all the way?” Ms. Duffy said. “Because we’ve heard that there’s a fire.”

Catherine Cowles, 69, lives on a quiet road in the foothills of Pasadena, Calif., where she enjoys occasionally glimpsing mountain lions or bobcats. Around 6:30 p.m. on Tuesday, a neighbor warned Ms. Cowles and her husband of a fire in the hills above the community. Ms. Cowles left a sheet of uncooked peanut butter cookies on the counter in her haste to flee.

The couple went to her stepdaughter’s home in Sierra Madre, just to the east. But within 90 minutes, that, too, felt too close to the Eaton fire for safety, and they set out for a friend’s home in central Pasadena.

Ms. Cowles has lived in Los Angeles for about 50 years, she said, but has never had to evacuate before.

“It makes it more scary, more real,” she said of having to flee twice. “Like this fire is just going to chew through the entire foothills and then just going to gobble everything in its path. Because at 100 miles per hour, what’s to stop it?”

Alain Delaquérière contributed research.